Related Experiment Video
Updated: Aug 29, 2026
Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
Published on: May 30, 2025
[The effect of stress on periodontitis model of guinea pigs]
1Department of Oral Medicine, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China. gsyun@163.com
Objective:
To investigate the effect of stress on Guinea Pigs' periodontitis model.
Methods:
24 periodontitis models of guinea pigs were provided by inoculating Actinobacillus actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) in the gingival sulcus. The guinea pigs were divided into two groups: stress group(stimulated with cold bath and fright) and control group(without stimulations). Three animals of each group were sacrificed successively at 1, 2, 4, 6 week after inoculation. Clinical and histological evaluation, cortisol concentration examinations, osteoclast and osteoblast numbers account were applied.
Results:
The cortisol concentration of stress group was significantly higher than that of control group at 1, 2, 4 week after stressed(P < 0.05 or P < 0.01). Pocket depth in stress group was significantly deeper than that in control group at 2, 4 week (P < 0.05), Compared with control group, the stress group demonstrated more active tissue damage and alveolar bone resorption. The bone repair in stress group was not as active as in control group. The osteoclast numbers in stress group was significantly higher than that in control group at 1, 4, 6 week (P < 0.05).
Conclusions:
Stress could enhance the destruction of periodontal tissues infected by pathogenic bacteria and increase disease susceptibility. It was concluded that stress was a significant risk indicator for periodontitis.
