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Updated: Aug 29, 2026
Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration
Published on: May 5, 2020
[Experimental study on using mGTR and venous autografts to repair facial nerve defects in rabbits]
Yue Ma1, Xin Xu, Ning-ning Xin
1Dental College, Shandong University, Jinan 250012, Shandong, China.
Objective:
To observe and compare the effects of using mGTR and venous autografts to repair the defect of facial nerve in rabbits.
Methods:
mGTR and venous autografts were performed on three groups of rabbits. Then physical and histological examinations were carried out to get the results of these two repair methods.
Results:
Both the two methods can induce regeneration of facial nerve. The mGTR is more effective and faster in repairing the nerve defect. Three months after operation, the distance of NCV between bilateral facial nerve in mGTR group was (2.10 +/- 1.2) m/s, (6.80 +/- 1.4) m/s in venous autografts, (2.16 +/- 1.6) m/s in nerve transplantation group. Histologically, the facial nerve fibers were arranged regularly and in continuity in mGTR, the facial nerve fibers were arranged irregularly with marked hyperplasia of connective tissues in venous autografts three months after repair.
Conclusions:
The mGTR is more effective than venous autografts in repair of facial nerve.
