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Related Experiment Videos

Fever during anaesthesia.

Chiharu Negishi1, Rainer Lenhardt

  • 1Department of Anaesthesia, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. bxh07473@nifty.com

Best Practice & Research. Clinical Anaesthesiology
|December 10, 2003
PubMed
Summary
This summary is machine-generated.

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General anesthesia and opioids can inhibit fever by lowering cold response thresholds. Epidural anesthesia does not affect fever, suggesting associated hyperthermia may be true inflammatory fever.

Area of Science:

  • Anesthesiology
  • Physiology
  • Immunology

Background:

  • Fever is a common perioperative response but rare during anesthesia.
  • Anesthesia's impact on fever is not well-understood.
  • General anesthesia and opioids appear to inhibit fever, while epidural anesthesia does not.

Purpose of the Study:

  • To explore the effects of different anesthesia types on fever.
  • To differentiate between anesthesia-induced hyperthermia and true fever.
  • To understand the implications for post-operative fever management.

Main Methods:

  • Review of existing literature on anesthesia and thermoregulation.
  • Analysis of studies investigating fever during general, opioid, and epidural anesthesia.
  • Comparison of thermoregulatory responses under different anesthetic conditions.

Related Experiment Videos

Main Results:

  • General anesthesia decreases thermoregulatory response thresholds to cold, inhibiting fever.
  • Opioids also inhibit fever, though to a lesser extent than general anesthesia.
  • Epidural anesthesia does not affect fever, suggesting associated hyperthermia may be inflammatory.

Conclusions:

  • Anesthesia significantly modulates the febrile response.
  • Hyperthermia during epidural anesthesia may represent a true inflammatory fever.
  • Post-operative fever, often non-infectious, should be managed judiciously, weighing risks and benefits.