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Diterpenoids from the stem barks of Croton robustus
Nattaya Ngamrojnavanich1, Sorasaree Tonsiengsom, Preecha Lertpratchya
1Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkom University, Bangkok 10330, Thailand.
Archives of Pharmacal Research
|December 10, 2003
Abstract:
Three compounds were isolated from the stem barks of Croton robustus. Their structures were elucidated as trachyloban-19-oic acid, trachyloban-19-ol and poilaneic acid by spectroscopic analysis. Among them, trachyloban-19-ol and methyl trachyloban-19-oate exhibited weak cytotoxic activity against gastric carcinoma and colon carcinoma with ED50 of 9.2, 9.6 and 8.3, 9.1 microg/mL, respectively.