Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dry skin in atopic dermatitis.

Y W Linde1

  • 1Department of Dermatology, Södersjukhuset, Stockholm, Sweden.

Acta Dermato-Venereologica. Supplementum
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) involves impaired skin barrier function, leading to dry skin. Studies show reduced water-binding capacity and altered stratum corneum lipids in AD patients, impacting skin hydration and texture.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Despite better knowledge of pathogenesis and treatment: atopic eczema--a disease with increasing incidence in Sweden].

Lakartidningen·1998
Same author

Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin.

The British journal of dermatology·1992
Same author

'Dry' skin in atopic dermatitis. I. A clinical study.

Acta dermato-venereologica·1989
Same author

'Dry' skin in atopic dermatitis. II. A surface profilometry study.

Acta dermato-venereologica·1989

Area of Science:

  • Dermatology
  • Skin Barrier Research
  • Biophysics of the Skin

Background:

  • Atopic dermatitis (AD) is a prevalent chronic skin condition characterized by impaired skin barrier function.
  • Dry skin is a frequent comorbidity in AD patients, yet the underlying barrier defects are not fully elucidated.
  • The stratum corneum, the outermost skin layer, plays a critical role in barrier function and was investigated in AD.

Purpose of the Study:

  • To investigate the biophysical properties of the stratum corneum in patients with atopic dermatitis.
  • To assess skin hydration, water loss, and surface characteristics in individuals with AD.
  • To explore potential alterations in stratum corneum lipids and cellular structures in AD.

Main Methods:

  • In vitro microbalance technique to measure water-binding capacity.

Related Experiment Videos

  • Evaporimeter and Corneometer to assess transepidermal water loss (TEWL) and water content.
  • Quantitative electron microscopy and scanning electron microscopy (SEM) for structural analysis.
  • Chromatographic analysis for stratum corneum lipid quantification.
  • Profilometry to evaluate skin surface roughness.

    • Main Results:

    • Reduced water-binding capacity and decreased water content in dry atopic skin.
    • Increased TEWL in dry and clinically normal skin on predilection areas of AD patients.
    • Quantitative electron microscopy revealed increased relative volume of lamellar bodies in dry atopic skin.
    • Preliminary chromatographic data suggested reduced extractable stratum corneum lipids.
    • SEM and profilometry showed a coarse, irregular surface pattern in dry atopic skin compared to normal skin.

    Conclusions:

    • Patients with atopic dermatitis exhibit significant alterations in stratum corneum biophysical properties.
    • Impaired barrier function in AD is associated with reduced hydration, increased water loss, and structural changes in the stratum corneum.
    • These findings highlight the critical role of the skin barrier in the pathophysiology of atopic dermatitis and suggest potential targets for management.