Related Experiment Video

Updated: Aug 29, 2026

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
10:16

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

Published on: February 10, 2012

Clinical utility of computed tomography and magnetic resonance techniques for noninvasive coronary angiography

Matthew J Budoff1, Stephan Achenbach, Andre Duerinckx

  • 1Division of Cardiology, Saint John's Cardiovascular Research Center, Harbor-UCLA Medical Center Research and Education Institute, Torrance, California 90502, USA. Budoff@flash.net

Journal of the American College of Cardiology
|December 10, 2003
PubMed

Insights

Noninvasive coronary angiography methods like electron beam angiography (EBA) show promise for detecting coronary artery disease (CAD). While not a complete replacement for conventional angiography, these techniques offer safer, cost-effective patient options.

Area of Science:

  • Cardiovascular imaging
  • Medical diagnostics
  • Radiology

Background:

  • Conventional coronary angiography (CCA) is invasive and costly.
  • Noninvasive coronary angiography (NIC) methods are advancing.
  • NIC aims to augment or replace CCA for diagnosing coronary artery disease (CAD).

Purpose of the Study:

  • To review literature on noninvasive coronary angiography (NIC).
  • Focus on electron beam angiography (EBA), magnetic resonance angiography (MRA), and spiral computed tomography (CT).
  • Evaluate these methods for visualizing coronary artery obstructions.

Main Methods:

  • Conducted MEDLINE searches for NIC studies.
  • Included magnetic resonance imaging (MRI), multi-row detector spiral computed tomography (MDCT), and electron beam tomography (EBT).
  • Performed weighted analysis to determine sensitivity and specificity.

Main Results:

  • Electron beam angiography (EBA) showed 87% sensitivity and 91% specificity for obstructive CAD.
  • Multi-row detector spiral CT (MDCT) had 59% sensitivity and 89% specificity, improving with newer devices.
  • Magnetic resonance angiography (MRA) demonstrated 77% sensitivity and 71% specificity.

Conclusions:

  • Noninvasive coronary angiography (NIC) is evolving and not yet a universal alternative to CCA.
  • EBA, MDCT, and MRA are used clinically at specialized centers.
  • Selective NIC use can be cost-effective and safer for patients deciding on treatment.
Abstract

More Related Videos

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...