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Increased uptake of T-kininogen by the liver in inflammatory conditions
M Takano1, K Yayama, Y Miyawaki
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
The distribution of [125I]T-kininogen in the liver of rats was found to be increased by laparotomy-, turpentine- or lipopolysaccharide-induced inflammation, whereas no such increase was observed in other organs or when 125I-labeled carboxymethylated T-kininogen, which does not inhibit cysteine proteinase, was used. These results suggest that the liver plays an important role in clearing T-kininogen from the circulation during inflammation.