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Isolation of a bradykinin-potentiating factor from scorpion Tityus serrulatus venom
1Department of Biochemistry, Butantan Institute, Sao Paulo, Brasil.
Abstract:
A bradykinin-potentiating factor was isolated and characterized from the scorpion Tityus serrulatus venom by chromatographic techniques and reverse phase followed by biological assays. This factor showed to be able to potentiate the contractile activity of the isolated guinea-pig ileum, inhibited the angiotensin-converting enzyme and potentiated the bradykinin-induced lowering of the arterial blood pressure in the rat.
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