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Pseudopeptide analogs of bradykinin and bradykinin antagonists
R J Vavrek1, L Gera, J M Stewart
1Department of Biochemistry, University of Colorado School of Medicine, Denver 80262.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
Over 100 reduced-bond analogs of bradykinin and bradykinin antagonists were designed, synthesized, and assayed in the classic smooth muscle and blood pressure assays in a further study of the structure-activity relationships of bradykinin. Both potent BK-like agonists and antagonists of BK activity were found among the reduced-bond analogs.