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Bradykinin antagonists do not require a D-aromatic amino acid residue at position 7
R J Vavrek1, L Gera, J M Stewart
1Department of Biochemistry, University of Colorado School of Medicine, Denver 80262.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
More than 200 new analogs of bradykinin have been synthesized and assayed. Analogs containing a D-aliphatic amino acid residue at position 7 and an L-aliphatic residue at position 8 are very potent antagonists of BK action on classical systems. Thus the "conventional wisdom" that a D-aromatic amino acid residue is required at sequence position 7 of BK antagonists must be modified.