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Major depression in multiple sclerosis: a population-based perspective.

S B Patten1, C A Beck, J V A Williams

  • 1Department of Community Health Sciences, University of Calgary, Alberta, Canada. patten@ucalgary.ca

Neurology
|December 10, 2003
PubMed
Summary
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Major depression is more common in people with multiple sclerosis (MS). This finding was observed in a large Canadian study and was not due to other health issues.

Area of Science:

  • Neurology
  • Psychiatry
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Depression is a common comorbidity in chronic illnesses.
  • Previous studies suggest a link between MS and depression, but population-based data controlling for other conditions are limited.

Purpose of the Study:

  • To determine the prevalence of major depression in a population-based sample of individuals with multiple sclerosis (MS).
  • To control for nonspecific illness effects and other long-term medical conditions when assessing depression rates in MS.
  • To investigate the association between MS and major depression in a large Canadian cohort.

Main Methods:

  • Utilized data from the Canadian Community Health Survey (CCHS), a large-scale national health survey.

Related Experiment Videos

  • Included 115,071 adult subjects (18+ years).
  • Assessed self-reported MS diagnoses and 12-month period prevalence of major depression using the Composite International Diagnostic Interview Short Form for Major Depression, controlling for other long-term conditions.

    • Main Results:

    • The prevalence of major depression was significantly elevated in individuals with MS compared to those without MS and those with other long-term conditions.
    • This association remained significant after adjusting for age and sex (adjusted odds ratio = 2.3).
    • Major depression prevalence was particularly high (25.7%) in individuals with MS aged 18 to 45 years.

    Conclusions:

    • The prevalence of major depression is demonstrably elevated in the population with multiple sclerosis.
    • This elevated rate is not an artifact of selection bias or other chronic conditions.
    • The findings highlight the need for increased awareness and screening for depression in individuals with MS.