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Updated: Aug 29, 2026
Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
Published on: December 20, 2024
Splenectomy for massive splenic infarction unmasks paroxysmal nocturnal hemoglobinuria
Costas Tsatalas1, Dimitris Margaritis, Despina Pantelidou
1Department of Hematology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. ktsatala@med.duth.gr
Abstract:
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by pancytopenia, hemolysis, and thrombosis. Abdominal vein thrombosis is a life-threatening manifestation of this disease. We present a patient with complete spleen necrosis due to thrombosis of the splenic vessels. After splenectomy, other causes of thrombophilia were excluded and the diagnosis of PNH was established. The patient was put on anticoagulation but despite the prophylactic international normalized ratio maintained over the last 18 months of follow-up, he had another episode of intrahepatic thrombosis which was treated with tissue plasminogen activator thrombolysis.