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Updated: Aug 29, 2026
Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
Published on: November 17, 2020
Isolated central nervous system (CNS) relapse in a case of childhood systemic anaplastic large cell lymphoma without
Tetsuya Mori1, Kenichi Sugita, Kyoko Kimura
1Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan. moreite@sc.itc.keio.ac.jp
Abstract:
Central nervous system (CNS) involvement in cases of anaplastic large cell lymphoma (ALCL) has been described only rarely. The authors describe an 11-year-old girl with ALCL who developed isolated CNS relapse but had no CNS disease at initial diagnosis and had received CNS-prophylactic treatment. The patient achieved a second remission following intensive treatment of the relapse and continues to be in remission at the time of writing. This case serves to emphasize that isolated CNS relapse without detectable initial CNS involvement can arise even after CNS-prophylactic treatment in pediatric ALCL cases.
