Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Salivary duct carcinoma.

A Sefik Hosal1, Chunyang Fan, Leon Barnes

  • 1Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|December 10, 2003
PubMed
Summary

Salivary duct carcinoma (SDC) is a rare, aggressive cancer. This study details 15 cases, highlighting common features like parotid gland location and extensive lymph node spread, guiding treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual-Modal Autofluorescence Microscopy for CycleGAN-Based H&E-like Image Generation in Liver Tissue: A Preliminary Proof-of-Concept Study.

Diagnostics (Basel, Switzerland)·2026
Same author

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
Same author

Hydroxysafflor yellow A attenuatesovariectomy induced bone loss andpromotes osteogenesis via PI3K/AKT activation in an in vitro BMSC model.

Scientific reports·2026
Same author

A Tale of 6 Chairs - Part 1 - David Myers.

Ear, nose, & throat journal·2026
Same author

Contemporary Management of Malignancies of the Parotid Gland: A State-of-the-Art Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

Transoral robotic surgery and neck dissection for hypopharyngeal cancer: long-term prognostic factors and survival outcomes.

Journal of robotic surgery·2026

Area of Science:

  • Oncology
  • Pathology

Background:

  • Salivary duct carcinoma (SDC) is a rare, aggressive malignancy.
  • SDC shares histological similarities with breast ductal carcinoma.
  • Understanding SDC's clinicopathologic features is crucial for effective management.

Purpose of the Study:

  • To present the clinicopathologic features of 15 patients diagnosed with salivary duct carcinoma.
  • To identify diagnostic indicators and common histological findings in SDC.
  • To evaluate treatment outcomes and suggest appropriate therapeutic strategies.

Main Methods:

  • Retrospective review of 15 SDC patient cases.
  • Analysis of clinicopathologic data, including patient demographics, tumor location, and presenting symptoms.
  • Histopathological examination of tumor characteristics, including invasion patterns and origin.

Related Experiment Videos

  • Review of diagnostic imaging (CT scans) for suggestive features.
  • Assessment of treatment modalities and patient outcomes.

    • Main Results:

    • The majority of patients were males aged 65+.
    • Parotid gland was the most common tumor site.
    • Suggestive diagnostic features included pain, facial palsy, and CT calcifications.
    • 27% of SDCs arose from pre-existing pleomorphic adenoma.
    • Perineural invasion, lymphatic invasion, and extensive cervical lymph node involvement (73%) were frequent.
    • Distant metastasis was the primary cause of treatment failure.

    Conclusions:

    • SDC is an aggressive salivary gland neoplasm with distinct clinicopathologic characteristics.
    • Early diagnosis aided by clinical and imaging findings is important.
    • Total parotidectomy with neck dissection and adjuvant radiation therapy are recommended for local and regional control.
    • The unpredictable clinical course necessitates comprehensive management strategies.