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Bone densitometry in patients with multiple myeloma
X Mariette1, P Khalifa, P Ravaud
1Service d'Immuno-hématologie, Hôpital Saint-Louis, Paris, France.
Purpose, Patients, And Methods:
We performed dual-energy x-ray absorptiometry in 10 selected patients with aggressive multiple myeloma in whom substantial tumor mass reduction was achieved after high-dose chemoradiotherapy followed by autologous blood stem cell transplantation.
Results:
In most cases, bone mineral density (BMD) of the spine was initially low (Mean Z score: -2.69, SEM 0.76) and dramatically increased after treatment (mean increase 16.4%; 7.7% with 95% confidence interval 2.2 to 12.2, excluding one patient whose spine BMD increased by 94.8%). In contrast, skeletal roentgenograms, computed tomographic scans, and magnetic resonance imaging did not reveal any significant improvement of patients' bone lesions.
Conclusions:
In patients with multiple myeloma, bone densitometry could be a useful way to assess the efficacy of treatment on bone status.