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Diabetic cutaneous microangiopathy.

M Rendell1, O Bamisedun

  • 1Creighton Diabetes Center, Omaha, Nebraska 68131.

The American Journal of Medicine
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

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Diabetic patients show reduced skin blood flow, particularly in nutritive microvasculature, correlating with diabetes duration and complications like retinopathy. This suggests skin can model diabetic microangiopathy.

Area of Science:

  • Diabetology
  • Vascular Biology
  • Dermatology

Background:

  • Diabetic microvascular complications affect various organs.
  • Skin microcirculation is a potential indicator of systemic diabetic changes.

Purpose of the Study:

  • To investigate the relationship between skin blood flow, diabetes duration, and microvascular complications.
  • To explore the potential of skin as a model for diabetic microangiopathy.

Main Methods:

  • Laser Doppler flowmetry used to measure skin blood flow in diabetic patients and controls.
  • Measurements taken at finger/toe pulps (arteriovenous anastomotic flow) and dorsums (nutritive microvasculature).
  • Correlation analysis with diabetes duration, retinopathy, proteinuria, and neuropathy.

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Main Results:

  • Diabetic patients exhibited reduced skin blood flow at elevated temperatures, especially at finger and toe dorsums.
  • Reduced flow correlated with longer diabetes duration and presence of retinopathy and proteinuria.
  • No significant differences in flow were observed at finger/toe pulps or in relation to neuropathy.

Conclusions:

  • A diabetic cutaneous microangiopathy exists, mirroring retinal and renal microvascular disease.
  • This microangiopathy primarily affects nutritive microvasculature.
  • The skin serves as a practical model for studying diabetic microangiopathy.