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[Heparin-induced extracorporeal LDL precipitation (H.E.L.P.)]
1Herz- und Diabeteszentrum NRW Kardiologische Klinik, Georgstr. 11, 32545, Bas Oeynhausen, Germany.
Zeitschrift Fur Kardiologie
|December 10, 2003
Summary
The H.E.L.P. (heparin-induced extracorporeal LDL precipitation) procedure effectively lowers LDL cholesterol and fibrinogen. This apheresis method improves endothelial function and coronary vasodilation capacity.
Area of Science:
- Cardiovascular Science
- Medical Technology
Context:
- Atherosclerosis is a major cardiovascular disease.
- Lipoproteins and fibrinogen contribute to atherosclerosis progression.
- Apheresis offers a method for selective blood purification.
Purpose:
- To evaluate the efficacy of the H.E.L.P. (heparin-induced extracorporeal LDL precipitation) procedure.
- To assess the impact of H.E.L.P. apheresis on lipoprotein and fibrinogen levels.
- To determine the effect of the procedure on adhesion molecules and coronary vasodilation.
Summary:
- The H.E.L.P. procedure utilizes heparin and pH reduction to selectively remove LDL cholesterol and fibrinogen (50-60% reduction).
- It also significantly lowers lipoprotein (a) and key adhesion molecules (ICAM-1, VCAM-1, P-selectin) implicated in atherosclerosis.
- Positron emission tomography confirmed improved coronary vasodilation capacity within 20 hours post-procedure.
Impact:
- The H.E.L.P. procedure demonstrates potential for managing atherosclerosis by improving endothelial function and rheology.
- Significant reduction in atherogenic factors and improved vascular function suggest therapeutic benefits.
- This apheresis technique offers a targeted approach to cardiovascular risk reduction.