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[Biorthythmological risk factors for progression of coronary heart disease]

N V Fomina, O L Barbarash, E V Mineeva

    Klinicheskaia Meditsina
    |December 11, 2003
    PubMed

    Insights

    Seasonal and birth-date related cycles significantly impact coronary heart disease (CHD) progression. Winter and autumn, along with specific birth-trimesters, show increased angina and ischemia in patients with CHD.

    Area of Science:

    • Cardiology
    • Chronobiology
    • Internal Medicine

    Context:

    • Coronary heart disease (CHD) progression is influenced by various factors.
    • Understanding the impact of individual annual cycles (IAC) and seasons on CHD is crucial for patient management.

    Purpose:

    • To investigate the role of seasons and specific periods within an individual annual cycle (IAC) on the progression of coronary heart disease (CHD).
    • To analyze clinical and functional parameters in patients with stable angina pectoris in relation to seasonal and IAC influences.

    Summary:

    • This study examined 52 patients with functional class II stable angina pectoris.
    • Findings indicate that autumn and winter are associated with increased angina progression.
    • 24-hour monitoring revealed increased silent ischemia and decreased heart rate variability in winter, and increased painful ischemia in autumn.
    • Specific IAC trimesters, particularly the fourth (months 10-12), showed a poorer CHD course with prolonged total and silent ischemia and increased latent coronary insufficiency.

    Impact:

    • Results highlight the significance of biorhythmological factors, including season and IAC periods, in determining the course of CHD.
    • This suggests potential for chronotherapeutic interventions in managing coronary heart disease.
    • Identifies specific high-risk periods for patients with stable angina pectoris, aiding in proactive healthcare strategies.

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