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[Clinical value of soluble adhesion molecules in systemic scleroderma]
Klinicheskaia Meditsina
|December 11, 2003
Summary
Scleroderma systematica (SS) patients show elevated cell adhesion soluble molecules (CASM). VCAM-1 is the most sensitive marker for disease activity in SS patients.
Area of Science:
- Immunology
- Rheumatology
Context:
- Scleroderma systematica (SS) is a complex autoimmune disease.
- Cell adhesion soluble molecules (CASM) play a role in inflammatory processes.
Purpose:
- To investigate the clinical significance of estimating CASM levels in patients with SS.
- To quantify VCAM-1, ICAM-1, and R-selectin levels in SS patients.
Summary:
- Elevated levels of VCAM-1, ICAM-1, and R-selectin were observed in a significant portion of SS patients.
- Mean VCAM-1 and ICAM-1 levels were significantly higher in SS patients compared to healthy donors.
- VCAM-1 levels were significantly higher in patients with active SS compared to those with chronic SS.
Impact:
- CASM, particularly VCAM-1, may serve as valuable biomarkers for assessing SS activity.
- Findings contribute to understanding thepathophysiology of SS and identifying potential therapeutic targets.