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Related Experiment Videos

Did the widespread use of long-acting calcium antagonists decrease the occurrence of variant angina?

Shozo Sueda1, Hiroaki Kohno, Hiroshi Fukuda

  • 1Department of Cardiology, Saiseikai Saijo Hospital, Tsuitachi 269-1, Saijo City, Ehime Prefecture, Japan 793-0027. EZF03146@nifty.or.jp

Chest
|December 11, 2003
PubMed
Summary

Variant angina (VA) frequency has decreased, likely due to increased use of long-acting calcium antagonists (L-CAs). This study retrospectively examined VA cases, finding a significant decline in recent years.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Variant angina (VA) prevalence has appeared to decline with the widespread adoption of long-acting calcium antagonists (L-CAs).
  • Retrospective analysis of VA frequency is crucial for understanding its current clinical significance.

Purpose of the Study:

  • To investigate the changing frequency of variant angina (VA) over a 12-year period.
  • To correlate observed trends with therapeutic interventions, particularly calcium antagonist use.

Main Methods:

  • Retrospective analysis of 349 patients with angiographically confirmed coronary spastic angina (CSA) from 1991-2002.
  • Classification of patients into four 3-year periods to assess temporal trends in VA and treatment modalities.
  • Spasm provocation tests were used for diagnosis, with VA defined by ST elevation during attacks or stress tests.

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Main Results:

  • The overall ratio of VA to CSA significantly decreased over the study period (32% to 5%).
  • While CSA diagnosis frequency remained stable, the number of VA cases and the VA/CSA ratio declined significantly in later years.
  • Administration of L-CAs increased substantially in the latter half of the study, correlating with the decrease in VA.

Conclusions:

  • The frequency of variant angina (VA) has demonstrably decreased in Japan.
  • Widespread therapeutic use of long-acting calcium antagonists (L-CAs) is a likely contributing factor to this observed decline.