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Mapping of the Darier's disease gene by serogenetic markers: results in two large British kindreds
C S Munro1, S S Mastana, S S Papiha
1University Department of Dermatology, University of Newcastle upon Tyne, UK.
Annales De Genetique
|January 1, 1992
Abstract:
The authors have carried out genetic linkage studies in 57 subjects from two large kindreds of Darier's disease, using a range of serological and biochemical polymorphisms of known chromosomal location. In these kindreds, about 7% of the genome has been excluded for close linkage to the Darier's disease gene. However, one family showed positive lod scores for linkage with the Duffy blood locus (1p13); lod scores were negative in the other family, but in the combined families the total score for this marker was still positive and does not completely exclude linkage.