Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C-anaphases: a mitotic variant.

M G Domínguez1, H Rivera

  • 1Division de Genética, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco.

Annales De Genetique
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a new peptide-bead coupling method for an all peptide-based Luminex multiplexing assay for detection of Plasmodium falciparum antibody responses.

Journal of immunological methods·2021
Same author

DID A del(2)(p11.2p13),inv(2)(p11.2q31) REARRANGEMENT RESULT FROM A GERMLINE RECIPROCAL INTRACHROMOSOME INSERTION?

Genetic counseling (Geneva, Switzerland)·2018
Same author

[Wolf-Hirschhorn syndrome: just a citation omission?]

Revista de neurologia·2017
Same author

Y-CHROMOSOME DE NOVO RECOMBINANTS. IMPLICATIONS FOR NOMENCLATURE.

Genetic counseling (Geneva, Switzerland)·2016
Same author

Short communication: Field fertility in Holstein bulls: Can type of breeding strategy (artificial insemination following estrus versus timed artificial insemination) alter service sire fertility?

Journal of dairy science·2016
Same author

p53 expression in oral lichenoid lesions and oral lichen planus.

General dentistry·2015
Same journal

Effect of 5637 conditioned medium (CM) on the mitotic index in the cytogenetic evaluation of myeloproliferative disorders.

Annales de genetique·2004
Same journal

Intranuclear arrangement of human chromosome 12 is reflected in metaphase chromosomes as non-random bending.

Annales de genetique·2004
Same journal

Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia.

Annales de genetique·2004
Same journal

Large duplication 4q25-q34 with mild clinical effect.

Annales de genetique·2004
Same journal

A submicroscopic unbalanced subtelomeric translocation t(2p;10q) identified by fluorescence in situ hybridization: fetus with increased nuchal translucency and normal standard karyotype with later growth and developmental delay, rhombencephalosynapsis (RES).

Annales de genetique·2004
Same journal

Partial trisomy 8q and partial monosomy 18p: a case report.

Annales de genetique·2004
See all related articles

Most individuals have less than 3% C-anaphases in lymphocyte cultures. A rare autosomal dominant form shows over 5% C-anaphases, but both are considered normal mitotic variants.

Area of Science:

  • Cytogenetics
  • Human Genetics
  • Cell Biology

Background:

  • C-anaphases, a chromosomal abnormality, are typically found at low frequencies in lymphocyte cultures.
  • Understanding the prevalence and significance of C-anaphases is crucial for genetic diagnostics.

Purpose of the Study:

  • To determine the frequency of C-anaphases in colchicine-arrested lymphocyte cultures across different patient groups.
  • To investigate the potential pathological significance of varying C-anaphase frequencies.

Main Methods:

  • Studied 100 patients across four groups: spontaneous abortion, subfertility, aneuploidy, and miscellaneous.
  • Scored at least 300 G-banded mitotic cells per individual.
  • Utilized statistical analysis to compare C-anaphase frequencies between groups.

Related Experiment Videos

Main Results:

  • No significant differences in C-anaphase frequency were found between patient groups (p > 0.05).
  • Most individuals (87/100) exhibited 1-7 C-anaphases (mean 2.14%), considered normal (< or = 3%).
  • One individual showed a high frequency (5.7%) consistent with an autosomal dominant form.

Conclusions:

  • Both common low-frequency and familial high-frequency C-anaphases represent normal mitotic variants.
  • These variants do not appear to have pathological significance in the studied populations.