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Acute epididymitis in boys: evidence of a post-infectious etiology
Eli Somekh1, Arkadi Gorenstein, Francis Serour
1Pediatric Infectious Diseaes Unit, Edith Wolfson Medical Center, Holon, Israel.
Insights
Pediatric epididymitis is common and often inflammatory, not strictly infectious. Most cases resolve with pain relief (analgesics), with antibiotics playing a minor role in treatment.
Area of Science:
- Pediatric Urology
- Infectious Diseases
- Pediatric Inflammation
Background:
- Epididymitis in children, while not rare, requires understanding its underlying causes and effective management strategies.
- Distinguishing between infectious and inflammatory etiologies is crucial for appropriate treatment.
Purpose of the Study:
- To investigate the causes (etiology) and optimal treatment (management) of epididymitis in pediatric patients.
- To determine the incidence and common pathogens associated with childhood epididymitis.
Main Methods:
- A 1-year prospective study involving 44 children (ages 2-14) diagnosed with epididymitis.
- Comprehensive diagnostic workup including scrotal sonography, microbiological cultures (urine, throat, nasopharynx, stool), and serological testing for specific pathogens (e.g., Mycoplasma pneumoniae, enteroviruses, adenoviruses).
Main Results:
- Epididymitis incidence was approximately 1.2 per 1,000 boys annually, with seasonal peaks in summer and winter.
- Serological evidence indicated a significant association with Mycoplasma pneumoniae, enteroviruses, and adenoviruses, suggesting a post-infectious inflammatory process in most cases.
- The majority of patients improved with analgesics alone, while only three required intravenous antibiotics; symptoms resolved within 1-7 days.
Conclusions:
- Pediatric epididymitis is a relatively common condition, predominantly presenting as an inflammatory response, likely post-infectious.
- Treatment primarily involves symptomatic relief with analgesics, with a limited role for antibiotic therapy.
Purpose:
We studied the etiology and management of pediatric epididymitis.
Material And Methods:
We performed 1-year prospective study in children with epididymitis. All patients underwent an immediate sonographic study of the scrotum. Microbiological studies included throat and urine cultures as well as viral cultures of nasopharyngeal and stool specimens. Serological tests for group A streptococcus and Mycoplasma pneumoniae as well as for enteroviruses, adenoviruses, influenza and parainfluenza viruses in the appropriate seasons were performed in patients and controls.
Results:
A total of 44 patients 2 to 14 years old (mean age 9.8 +/- 3.2) were studied. Hospital admissions peaked during the summer and winter. The incidence of epididymitis was around 1.2/1,000 boys yearly. One patient had familial Mediterranean fever and another had Henoch-Schonlein purpura. Microbiological studies of the urine, throat, nasopharynx and stool yielded bacterial/viral growth in 9 patients (20.4%). Serological studies revealed significantly elevated titers to certain pathogens in patients with epididymitis compared with controls, including M. pneumoniae (53% vs 20%), enteroviruses (62.5% vs 10%) and adenoviruses (20% vs 0%). Most patients were treated with analgesics and 3 patients received antibiotics intravenously. Systemic and local signs and symptoms resolved gradually in 1 to 7 days.
Conclusions:
Our results suggest that epididymitis in boys is not rare and it is mostly an inflammatory phenomenon (presumably post-infectious) with a benign course. The treatment of these patients is basically with analgesics with a little role for antibiotics.
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