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Synthesis of biologically active [2.2]paracyclophanes
A A Aly1, A A Hassan, A F Mourad
1Chemistry Department, Faculty of Science, El-Minia University, Egypt.
Archiv Der Pharmazie
|October 1, 1992
Abstract:
Claisen reaction of 4-acetyl[2.2]paracyclophane (1) with ethyl acetate and diethyl oxalate affords 4-acetoacetyl[2.2]paracyclophane (2) and ethyl (4-oxaloacetyl[2.2]paracyclophane) (6), respectively. Reaction of 2 and 6 with hydrazines and CuCl2 gave the pyrazole derivatives 4 and 8 in addition to the metal complexes 5 and 9. Mannich reaction of 2 with benzylamine and paraformaldehyde yielded the piperidinone derivative 3. The biological activity of all new compounds was tested.