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Updated: Aug 29, 2026

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
Published on: February 25, 2016
Nuclear localization of beta-catenin is correlated with the expression of cyclin D1 in endometrial carcinomas
Hsien-Chang Shih1, Tanri Shiozawa, Tsutomu Miyamoto
1Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Background:
beta-catenin has recently been reported to act as a cell growth promoter through cyclin D1 transcription. However, the correlation between beta-catenin and cyclin D1 expressions is not fully understood in endometrial tissues.
Materials And Methods:
Immunohistochemical expression of beta-catenin was examined in normal endometria (32 cases) and endometrial carcinomas (82 cases), and its expression was compared with that of cyclins (D1, E, A, B1).
Results:
Sporadic nuclear staining of beta-catenin and cyclins was observed from proliferative phase of early secretory phase endometria, however, spacial correlations between beta-catenin and cyclins were not evident. In endometrial carcinomas, positivity for nuclear beta-catenin and cyclins increased compared to the normal endometria. Topologically, the cyclin D1-positive cells were frequently found in nuclear beta-catenin-positive cells. In addition, Spearman's rank correlation analysis revealed that the nuclear expression of beta-catenin correlated positively with that of cyclin D1 (p < 0.0001).
Conclusion:
The beta-catenin-cyclin D1 pathway might be involved in the growth of endometrial carcinomas.
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