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Related Experiment Videos

Neuroselective current perception threshold evaluation of bladder mucosal sensory function.

Osamu Ukimura1, So Ushijima, Hisashi Honjo

  • 1Department of Urology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan. akimura@koto.kpu-m.ac.jp

European Urology
|December 12, 2003
PubMed
Summary

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Current Perception Threshold (CPT) measures can quantify bladder sensory function in neuropathic conditions. This neuroselective technique identifies hypersensitivity or hyposensitivity, aiding therapeutic strategy selection for urinary dysfunction.

Area of Science:

  • Urology
  • Neuroscience
  • Sensory Physiology

Background:

  • Assessing human bladder mucosal sensory function is crucial for diagnosing and managing urinary disorders.
  • Conventional urodynamic tests have limitations in precisely evaluating specific nerve fiber functions within the bladder mucosa.

Observation:

  • Neuroselective Current Perception Threshold (CPT) measurements were successfully obtained from the bladder mucosa in healthy volunteers and patients with neuropathic bladders.
  • CPT values at different frequencies (5Hz, 250Hz, 2000Hz) selectively assess C-fiber, A-delta-fiber, and A-beta-fiber function, respectively.

Findings:

  • Patients with detrusor hyperreflexia showed significantly lower bladder CPT values at 5Hz, indicating hypersensitivity.
  • Patients with underactive neurogenic bladders exhibited higher CPT values across all frequencies, suggesting hyposensitivity.

Related Experiment Videos

  • CPT measurements were feasible in most patients, with exceptions only in cases of complete spinal cord injury with absent sensation.

    • Implications:

    • Quantitative neuroselective CPT measurement is a feasible method for evaluating human bladder mucosal sensory function.
    • This technique allows for the objective determination of sensory hypersensitivity or hyposensitivity in neuropathic bladders.
    • CPT-based assessment can guide the selection of appropriate therapeutic strategies for patients with urinary sensory dysfunction.