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Hemarthrosis in acquired hemophilia. Two case-reports
Daniel Wendling1, Marie-Anne Bertrand
1Rheumatology Department, Jean Minjoz Teaching Hospital, 25030 Besançon, France. daniel.wendling@ufc-chu.univ-comte.fr
Joint Bone Spine
|December 12, 2003
Summary
Acquired hemophilia, an autoimmune condition targeting factor VIII, can cause hemarthrosis. Early diagnosis and treatment lead to favorable outcomes in these rare cases.
Area of Science:
- Hematology
- Immunology
- Autoimmune diseases
Background:
- Hemarthrosis, or joint bleeding, has multiple causes.
- Acquired hemophilia arises from autoantibodies against factor VIII.
- This condition is rare but clinically significant.
Purpose of the Study:
- To present two distinct cases of acquired hemophilia.
- To discuss the diagnosis, etiology, prognosis, and treatment of acquired hemophilia.
Main Methods:
- Case report 1: A woman with juvenile idiopathic arthritis developed acquired hemophilia post-partum.
- Case report 2: An elderly woman presented with spontaneous hemarthrosis and hematomas.
- Review of diagnosis, etiology, prognosis, and treatment strategies.
Main Results:
- Both patients, despite different presentations, received appropriate treatment including immunosuppressants and factor replacement therapies.
- Both patients achieved full recovery within one year.
- Acquired hemophilia was confirmed by laboratory findings like isolated APTT prolongation, low factor VIII activity, and presence of factor VIII inhibitors.
Conclusions:
- Acquired hemophilia is a rare but important cause of hemarthrosis.
- Prompt diagnosis and tailored treatment are crucial for a positive prognosis.
- This condition warrants consideration in patients presenting with unexplained bleeding, especially hemarthrosis.