Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell tolerance.

D Lo1

  • 1Scripps Research Institute, La Jolla, California.

Current Opinion in Immunology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

T-cell tolerance involves complex thymic and peripheral mechanisms. New findings reveal diverse thymic cells contribute to deleting self-reactive T cells, while bone marrow cells can induce tolerance peripherally.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Building an oncology community of practice to improve cancer care.

Current oncology (Toronto, Ont.)·2019
Same author

Oncology communities of practice: insights from a qualitative analysis.

Current oncology (Toronto, Ont.)·2019
Same author

MAVEN observations of the response of Mars to an interplanetary coronal mass ejection.

Science (New York, N.Y.)·2015
Same author

Early MAVEN Deep Dip campaign reveals thermosphere and ionosphere variability.

Science (New York, N.Y.)·2015
Same author

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF.

Oncogene·2014
Same author

Sol-gel silica laser tunable in the blue.

Applied optics·2010
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Area of Science:

  • Immunology
  • T-cell biology
  • Self-tolerance mechanisms

Background:

  • Established principles of T-cell tolerance include thymic clonal deletion and peripheral clonal anergy.
  • Recent research highlights emerging complexities in understanding T-cell self-tolerance.
  • Autoreactive T cells pose a risk for autoimmune diseases if not properly controlled.

Purpose of the Study:

  • To explore novel aspects and challenges in T-cell tolerance research.
  • To investigate the multifaceted roles of thymic components in T-cell deletion.
  • To examine the conditions under which peripheral antigen-presenting cells induce tolerance.

Main Methods:

  • Review and synthesis of current literature on T-cell tolerance.
  • Analysis of experimental data regarding thymic epithelial cell subsets.

Related Experiment Videos

  • Investigation of bone marrow-derived antigen-presenting cell function in peripheral tolerance.

    • Main Results:

    • Multiple thymic cell subsets, including various thymic epithelial cells, actively participate in deleting autoreactive T cells.
    • Peripheral T-cell anergy induction is influenced by the tolerogenic potential of bone marrow-derived antigen-presenting cells.
    • The precise conditions dictating tolerogenic versus stimulatory functions of antigen-presenting cells require further elucidation.

    Conclusions:

    • T-cell tolerance is a dynamic process involving intricate interactions within the thymus and periphery.
    • Understanding the diverse cellular contributions is crucial for advancing T-cell tolerance research.
    • Further investigation into antigen-presenting cell function is needed to fully grasp peripheral tolerance induction.