Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell subsets in autoimmunity.

D Mason1, D Fowell

  • 1MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford, UK.

Current Opinion in Immunology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of the Rare Decay of the η Meson to Four Muons.

Physical review letters·2023
Same author

Observation of Same-Sign WW Production from Double Parton Scattering in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2023
Same author

Measurements of jet multiplicity and jet transverse momentum in multijet events in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023
Same author

Search for Higgs Boson Decay to a Charm Quark-Antiquark Pair in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2023
Same author

Azimuthal Correlations within Exclusive Dijets with Large Momentum Transfer in Photon-Lead Collisions.

Physical review letters·2023
Same author

Azimuthal correlations in Z +jets events in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Certain T-cell subsets regulate autoimmune diseases. Researchers identified CD4+ T cells that inhibit autoimmunity and CD8+ T cells that protect against it, offering new therapeutic targets for autoimmune conditions.

Area of Science:

  • Immunology
  • Autoimmunity
  • Cell Biology

Background:

  • Functional T-cell subsets are distinguished by CD45 isoforms.
  • T-cell subsets play critical roles in the development and regulation of autoimmune diseases.
  • Previous research suggests a link between superantigens and autoimmune diabetes pathogenesis.

Purpose of the Study:

  • To investigate the role of T-cell subsets defined by CD45 isoforms in autoimmunity.
  • To identify specific T-cell populations that can inhibit or protect against autoimmune diseases.
  • To explore the mechanisms underlying T-cell-mediated regulation of autoimmune responses.

Main Methods:

  • Analysis of T-cell subsets expressing different CD45 isoforms.
  • In vitro activation of T cells using Staphylococcal enterotoxin in a rat model of diabetes.

Related Experiment Videos

  • Assessment of T-cell populations involved in the induction and inhibition of autoaggressive responses.
  • Evaluation of CD8+ T-cell-mediated protection and transforming growth factor-beta synthesis.

    • Main Results:

    • A subset of CD4+ T cells capable of inhibiting autoimmune disease was identified.
    • In the B-B rat diabetes model, T cells activated by superantigens can induce disease, but a regulatory T-cell subset can inhibit this process.
    • Evidence suggests CD8+ T cells can be protective in experimental autoimmune diseases, potentially via transforming growth factor-beta production.

    Conclusions:

    • T-cell subsets defined by CD45 expression have distinct roles in autoimmunity.
    • Both CD4+ and CD8+ T cells can exert regulatory or protective functions in autoimmune diseases.
    • Targeting specific T-cell subsets may offer novel therapeutic strategies for managing autoimmune conditions.