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Role of type 1 and type 2 T helper cells in allergic diseases
M L Kapsenberg1, H M Jansen, J D Bos
1Laboratory of Cell Biology and Histology, University of Amsterdam, The Netherlands.
Current Opinion in Immunology
|December 1, 1992
Abstract:
Various characteristics of atopic allergic disorders seem to be causally related with the activation of allergen-specific T helper lymphocytes with a type 2 cytokine secretion profile, including high levels of interleukin-4 and interleukin-5. These cytokines are responsible for the occurrence of elevated levels of serum allergen-specific IgE and eosinophilia and play an important role in local inflammatory reactions.