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LOX-DB-- database on lipoxygenases.

T Lütteke1, P Krieg, G Fürstenberger

  • 1Central Spectroscopic Department, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. t.luettke@dkfz.de

Bioinformatics (Oxford, England)
|December 12, 2003
PubMed
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The Lipoxygenases database (LOX-DB) provides a comprehensive resource for mammalian lipoxygenases, enzymes implicated in diseases like cancer and inflammation. It offers molecular structures, data, and analysis tools for researchers.

Area of Science:

  • Biochemistry
  • Enzymology
  • Bioinformatics

Background:

  • Lipoxygenases are enzymes linked to various human diseases, including inflammation, asthma, atherosclerosis, and cancer.
  • A comprehensive database is needed to consolidate information on this multigene enzyme family, particularly mammalian members.

Purpose of the Study:

  • To establish a web-accessible compendium of information on mammalian lipoxygenases.
  • To provide researchers with tools for structural and computational analysis of lipoxygenases.

Main Methods:

  • Data compilation of molecular structures and reference information for lipoxygenases.
  • Development of search functionalities for data retrieval.
  • Integration of publicly available visualization tools for data analysis.

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Main Results:

  • The Lipoxygenases database (LOX-DB) is now available online.
  • The database includes molecular structures, reference data, and computational analysis tools.
  • Users can retrieve and analyze lipoxygenase data through various search options and visualization tools.

Conclusions:

  • LOX-DB serves as a valuable resource for studying lipoxygenases and their roles in human diseases.
  • The database facilitates research in areas such as inflammation, asthma, atherosclerosis, and cancer.
  • Web accessibility and integrated tools enhance the utility of LOX-DB for the scientific community.