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TOR signaling

Thurl E Harris1, John C Lawrence

  • 1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Science'S STKE : Signal Transduction Knowledge Environment
|December 12, 2003
PubMed

Insights

The mammalian target of rapamycin (mTOR) pathway regulates cell growth. This review details recent advances in understanding mTOR pathway control and its interacting proteins.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The mammalian target of rapamycin (mTOR) is a key Ser-Thr kinase.
  • mTOR signaling controls cell growth and proliferation.
  • mTOR activity is influenced by nutrients, hormones, and growth factors.

Purpose of the Study:

  • To review recent progress in understanding mTOR pathway regulation.
  • To explore the role of mTOR-interacting proteins.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of signaling pathways involving mTOR, Akt, TSC1/TSC2, and Rheb.
  • Examination of mTOR protein complexes.

Main Results:

  • The mTOR pathway integrates signals from amino acids, hormones, and growth factors.
  • Key regulators include Akt, TSC1/TSC2, and Rheb.
  • mTOR forms complexes with raptor and mLST8.

Conclusions:

  • Significant advancements have been made in elucidating mTOR pathway control.
  • Understanding mTOR-interacting proteins is crucial for comprehending its function.

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