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Related Experiment Videos

TOR signaling.

Thurl E Harris1, John C Lawrence

  • 1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Science'S STKE : Signal Transduction Knowledge Environment
|December 12, 2003
PubMed
Summary
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The mammalian target of rapamycin (mTOR) pathway regulates cell growth. This review details recent advances in understanding mTOR pathway control and its interacting proteins.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The mammalian target of rapamycin (mTOR) is a key Ser-Thr kinase.
  • mTOR signaling controls cell growth and proliferation.
  • mTOR activity is influenced by nutrients, hormones, and growth factors.

Purpose of the Study:

  • To review recent progress in understanding mTOR pathway regulation.
  • To explore the role of mTOR-interacting proteins.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of signaling pathways involving mTOR, Akt, TSC1/TSC2, and Rheb.
  • Examination of mTOR protein complexes.

Main Results:

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  • The mTOR pathway integrates signals from amino acids, hormones, and growth factors.
  • Key regulators include Akt, TSC1/TSC2, and Rheb.
  • mTOR forms complexes with raptor and mLST8.

    • Conclusions:

    • Significant advancements have been made in elucidating mTOR pathway control.
    • Understanding mTOR-interacting proteins is crucial for comprehending its function.