New developments in idiopathic thrombocytopenic purpura (ITP): cooperative, prospective studies by the...

Based on 6 years of experience with worldwide cooperation of investigators in the field of hematology, the International Childhood ITP Study Group (ICIS) has provided a long-term concept for prospective studies and new, evidence-based definitions of idiopathic thrombocytopenic purpura (ITP). Structured interactions between the cooperating investigators, the ICIS board, the writing committees, an expert panel, and the central operative office are summarized in the Rules of the ICIS. Preliminary experience shows high acceptance of the activities of the ICIS by participants from many countries. There is good cooperation, resulting in analyses and publication of results. New areas of focus for ICIS include the formation of an expert panel, regular meetings, and publication of results from current studies. Long-term financial resources must be found. ICIS is looking back on 6 constructive years of international cooperation resulting in new or confirmatory evidence regarding the demographics, diagnosis, natural history, and management of childhood ITP. New structures and cooperation must be identified to continue this productive endeavor.