Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipid abnormalities in insulin resistant states.

Karol E Watson1, Barbara N Horowitz, Gary Matson

  • 1Division of Cardiology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Reviews in Cardiovascular Medicine
|December 12, 2003
PubMed
Summary

Insulin resistance leads to metabolic issues like type 2 diabetes and unhealthy cholesterol levels. Early detection and treatment of these lipid abnormalities are crucial for reducing cardiovascular disease risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neighborhood-Level Racial and Ethnic Residential Segregation and Incidence of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis.

Journal of the American Heart Association·2026
Same author

Association between Lipoprotein(a) and diet quality with cardiovascular disease risk: the multi-ethnic study of atherosclerosis.

American journal of preventive cardiology·2026
Same author

iCARDIO Alliance global implementation guidelines for the management of obesity 2025 focus on prevention and treatment of cardiometabolic disease.

American journal of preventive cardiology·2026
Same author

Disparities in Cardiovascular Medicine: Evidence Is Not Enough, Policy Change Is Essential.

Circulation·2026
Same author

Association of Subclinical Cardiac Remodeling With Incident Cancer in the MESA Cohort.

Journal of the American Heart Association·2026
Same author

Correction to: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Circulation·2026

Area of Science:

  • Metabolic Medicine
  • Cardiovascular Health
  • Endocrinology

Background:

  • Insulin resistance is linked to numerous metabolic dysfunctions.
  • Key associated conditions include type 2 diabetes mellitus, hypertension, central obesity, and dyslipidemia.
  • These conditions significantly increase cardiovascular disease (CVD) risk.

Purpose of the Study:

  • To outline the metabolic consequences of insulin resistance.
  • To detail the specific lipid abnormalities characterizing atherogenic dyslipidemia in insulin-resistant states.
  • To emphasize the importance of early identification and management of insulin resistance and associated lipid profiles.

Main Methods:

  • Review of existing literature on insulin resistance and its metabolic sequelae.

Related Experiment Videos

  • Analysis of the characteristic features of atherogenic dyslipidemia.
  • Correlation of lipid abnormalities with cardiovascular risk factors.

    • Main Results:

    • Insulin resistance is associated with type 2 diabetes, hypertension, obesity, and dyslipidemia.
    • Atherogenic dyslipidemia involves hypertriglyceridemia, increased VLDL, increased small, dense LDL, and decreased HDL cholesterol.
    • Each lipid abnormality is an independent CVD risk factor, with combined effects magnifying risk.

    Conclusions:

    • Insulin resistance precipitates a cascade of metabolic issues, notably atherogenic dyslipidemia.
    • The identified lipid abnormalities collectively pose a significant threat to cardiovascular health.
    • Early diagnosis of insulin resistance and prompt treatment of dyslipidemia are essential for mitigating CVD risk.