Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Therapy for calciphylaxis: an outcome analysis.

Jorge E Arch-Ferrer1, Samuel W Beenken, Loring W Rue

  • 1Department of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA.

Surgery
|December 12, 2003
PubMed
Summary

Parathyroid resection significantly improves survival for patients with calciphylaxis. This surgery lowers key biochemical markers and leads to better clinical outcomes compared to non-surgical management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical Oncology Heroes and Legends: Edward M. Copeland III, MD, as Interviewed by Kirby I. Bland, MD, FACS, MAMSE.

Annals of surgical oncology·2024
Same author

Surgical Oncology Heroes and Legends: Kirby I. Bland MD, FACS, MAMSE as Interviewed by V. Suzanne Klimberg, MD, PhD, MSHCT, MAMSE.

Annals of surgical oncology·2024
Same author

Less Toxic Chemotherapy in Locally Advanced Breast Cancer.

Southern medical journal·2020
Same author

Transition of Editor - in - Chief for The American Journal of Surgery.

American journal of surgery·2020
Same author

Fluorescence Imaging of Nerves During Surgery.

Annals of surgery·2019
Same author

Treatment patterns for ductal carcinoma in situ with close or positive mastectomy margins.

The Journal of surgical research·2018

Area of Science:

  • Nephrology
  • Dermatology
  • Surgical Oncology

Background:

  • Calciphylaxis presents as painful skin lesions, ulcerations, and gangrene, often linked to secondary hyperparathyroidism.
  • This condition is challenging to treat and can lead to severe complications, including sepsis and mortality.

Purpose of the Study:

  • To evaluate the effectiveness of parathyroid resection in managing calciphylaxis.
  • To compare survival rates and biochemical markers between surgical and non-surgical treatment groups.

Main Methods:

  • Retrospective analysis of patient data from 1993 to 2001.
  • Statistical comparison of patient, disease, and treatment variables using t-tests, chi-square, and Fisher's exact tests.
  • Kaplan-Meier survival analysis with log-rank testing.

Related Experiment Videos

Main Results:

  • Thirty-five patients were treated, with 66% undergoing parathyroid resection.
  • Surgical intervention led to significant improvements in serum calcium, phosphate, and parathyroid hormone levels (P<.05).
  • Patients who underwent surgery had a median survival of 80 months, compared to 35 months for non-surgical patients (P<.001).

Conclusions:

  • Parathyroid resection is an effective treatment for calciphylaxis.
  • The procedure normalizes key biochemical markers associated with the condition.
  • Surgical management of calciphylaxis is associated with improved clinical response and significantly longer overall survival.