Ace revisited: a new target for structure-based drug design

Hydroxamate-based inhibitors reveal structural determinants of selectivity for Plasmodium falciparum aminopeptidase P.

The Journal of biological chemistry·2026

Kinetic and structural characterisation of domain-specific angiotensin I-converting enzyme inhibition by captopril, rentiapril and zofenoprilat.

The FEBS journal·2026

Structural basis for inhibition of Mycobacterium tuberculosis α-methylacyl-CoA racemase by 2-arylthiopropanoyl-CoA inhibitor analogs.

The Journal of biological chemistry·2025

Ciprofloxacin Inhibits Angiotensin I‑Converting Enzyme (ACE) Activity by Binding at the Exosite, Distal to the Catalytic Pocket.

ACS bio & med chem Au·2025

Molecular basis of domain-specific angiotensin I-converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat.

The FEBS journal·2025

Biochemical and structural insights into GMHpaB: A thermostable 4-Hydroxyphenylacetate-3-monooxygenase with dual cofactor versatility.

International journal of biological macromolecules·2025

Artificial intelligence in drug discovery - what it is, where we stand and the path forward.

Nature reviews. Drug discovery·2026

Targeting T follicular helper cells for lifelong health.

Nature reviews. Drug discovery·2026

Design, simulate, refine: simulation-guided clinical trials for accelerated drug development.

Nature reviews. Drug discovery·2026

Total Synthesis of Paliurine E by a Highly Convergent Block Approach.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

Ring-opening simplification of thiazolyl-pyrazoline-triazole hybrids: synthesis, SAR and antifolate mechanism against Leishmania major.

RSC medicinal chemistry·2026

Metal-drug coordinated nanozymes for ROS scavenging and Kupffer cell polarization to alleviate drug-induced liver injury.

Acta pharmaceutica Sinica. B·2026

Rationale of renewed efforts in developing MC4R modulators to treat metabolic disorders.

Acta pharmaceutica Sinica. B·2026

SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics.

International journal of molecular sciences·2026

Biological Evaluation, Molecular Docking, and in Ovo Hatchability Assessment of Selected Mannich-Type 1,2,4-Triazol-5-one Derivatives.

International journal of molecular sciences·2026

Related Experiment Videos

Ace revisited: a new target for structure-based drug design

Related Concept Videos

Hydroxamate-based inhibitors reveal structural determinants of selectivity for Plasmodium falciparum aminopeptidase P.

Kinetic and structural characterisation of domain-specific angiotensin I-converting enzyme inhibition by captopril, rentiapril and zofenoprilat.

Structural basis for inhibition of Mycobacterium tuberculosis α-methylacyl-CoA racemase by 2-arylthiopropanoyl-CoA inhibitor analogs.

Ciprofloxacin Inhibits Angiotensin I‑Converting Enzyme (ACE) Activity by Binding at the Exosite, Distal to the Catalytic Pocket.

Molecular basis of domain-specific angiotensin I-converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat.

Biochemical and structural insights into GMHpaB: A thermostable 4-Hydroxyphenylacetate-3-monooxygenase with dual cofactor versatility.

Artificial intelligence in drug discovery - what it is, where we stand and the path forward.

Targeting T follicular helper cells for lifelong health.

Design, simulate, refine: simulation-guided clinical trials for accelerated drug development.

Total Synthesis of Paliurine E by a Highly Convergent Block Approach.

Ring-opening simplification of thiazolyl-pyrazoline-triazole hybrids: synthesis, SAR and antifolate mechanism against Leishmania major.

Metal-drug coordinated nanozymes for ROS scavenging and Kupffer cell polarization to alleviate drug-induced liver injury.

Rationale of renewed efforts in developing MC4R modulators to treat metabolic disorders.

SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics.

Biological Evaluation, Molecular Docking, and in Ovo Hatchability Assessment of Selected Mannich-Type 1,2,4-Triazol-5-one Derivatives.

Related Experiment Videos

Ace revisited: a new target for structure-based drug design

Related Concept Videos

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