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Published on: May 14, 2013
Subacute stent thrombosis following coronary angioplasty: incidence and risk factors
Maciej Lesiak1, Stefan Grajek, Małgorzata Pyda
1I Department of Cardiology, Medical Academy, Poznań, Poland.
Insights
Urgent stenting, inadequate pre-treatment, and suboptimal procedural outcomes are key risk factors for subacute stent thrombosis, a serious complication following coronary stenting.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
Background:
- Subacute stent thrombosis was a major complication of early coronary stenting.
- Intracoronary ultrasound improved identification and treatment, reducing thrombosis rates to 1%.
Purpose of the Study:
- To identify risk factors associated with subacute stent thrombosis.
Main Methods:
- Analysis of 845 single stent implantation procedures.
- Patient cohort included those with stable or unstable angina between 1998-2000.
Main Results:
- Subacute stent thrombosis occurred in 1.54% of patients (13 cases).
- Identified risk factors: urgent (bailout) stenting, improper drug pre-treatment, uncovered dissection, and poor final results (residual stenosis).
- Most affected patients experienced myocardial infarction despite prompt vessel patency.
Conclusions:
- Urgent stenting is a significant risk factor.
- Inadequate pre-treatment with medications increases thrombosis risk.
- Suboptimal procedural results are linked to subacute stent thrombosis.
Background:
Subacute stent thrombosis was a significant complication in the early years of coronary stenting, often leading to myocardial infarction, need for urgent surgery or even death. The introduction of intracoronary ultrasound enabled the identification and proper treatment of the main causes of stent thrombosis, reducing the rate of this complication to 1%.
Aim:
To identify risk factors of subacute stent thrombosis.
Methods:
Data concerning 845 procedures with a single stent implantation in patients with stable or unstable angina, undergoing this procedure between 1998 and 2000, were analysed.
Results:
Subacute stent thrombosis occurred in 13 (1.54%) patients. Risk factors for this complication included urgent procedures (so-called bailout stenting), improper pre-treatment with drugs ("ad hoc" procedures), dissection uncovered by stent, and poor final result of procedure (higher degree of residual stenosis). The majority of these patients developed myocardial infarction in spite of the fact that the patency of stented vessel was quickly achieved in all but one patient.
Conclusions:
Urgent stenting, improper drug pre-treatment and suboptimal result of the procedure are the risk factors of subacute stent thrombosis.
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