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Modeling coincidence detection in nucleus laminaris

Victor Grau-Serrat1, Catherine E Carr, Jonathan Z Simon

  • 1Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA.

Biological Cybernetics
|December 12, 2003
PubMed

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Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...