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Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa
M Ashik Mosaddik1, M Ekramul Haque
1Centre for Phytochemistry, Southern Cross University, Lismore, NSW 2480, Australia. mamosaddik@yahoo.com
Abstract:
The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC50 values (5.03 microg/mL) comparable with the reference standard agent, gallic acid. It also showed weak antibacterial and significant antifungal activity against a wide range of gram positive and gram negative bacteria and fungi. The antibacterial (minimum inhibitory concentration) effect against Bacillus cereus and Shigella shiga was found to be 64 microg/mL.
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