Risk of recurrent intracerebral hemorrhages

Ralf Buhl1, Harald Barth, Hubertus M Mehdorn

  • 1Department of Neurosurgery, University of Kiel, Weimarer Str. 8, 24106 Kiel, Germany. buhlr@nch.uni-kiel.de

Neurological Research
|December 13, 2003
PubMed

Insights

Recurrent intracerebral hemorrhage (ICH) affects nearly 5% of patients, with re-bleeding occurring within three years. Outcomes worsen after a second ICH, with fewer patients undergoing surgery.

Area of Science:

  • Neurology
  • Neurosurgery
  • Stroke Medicine

Background:

  • Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes.
  • Hypertension and cerebral amyloid angiopathy (CAA) are primary causes of ICH.
  • Surgical evacuation for ICH, especially in elderly patients, remains controversial.

Purpose of the Study:

  • To investigate the incidence and characteristics of recurrent ICH.
  • To analyze the clinical outcomes and treatment patterns for patients experiencing a second ICH.

Main Methods:

  • Retrospective review of 968 ICH patients treated at the department.
  • Analysis of 48 patients with recurrent hemorrhages, including time interval and surgical intervention rates.

Main Results:

  • The incidence of recurrent ICH was 4.9% (48/968 patients).
  • The mean interval between the first and second hemorrhage was three years.
  • Surgical intervention decreased from 77% for the first hemorrhage to 50% for the second.

Conclusions:

  • Recurrent ICH is a significant complication with a notable incidence.
  • Clinical outcomes appear more severe after a second ICH, with reduced surgical rates.
  • Close follow-up and hypertension management are crucial for preventing re-bleeding in ICH patients.

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...