[Locus DYS 439--polymorphism in Polish population]

Area of Science:

• Forensic Genetics
• Population Genetics
• Human Genetics

Background:

• Y-STR loci are crucial for forensic identification and population studies.
• Understanding genetic diversity within and between populations is key for accurate forensic analysis.
• The DYS439 locus is a Y-short tandem repeat marker with potential for population-specific investigations.

Purpose of the Study:

• To characterize the polymorphism of the novel DYS439 locus in a Polish male population.
• To establish a sequenced allelic ladder for accurate DYS439 typing.
• To compare the allele frequency distribution of DYS439 between the Polish population and other European populations.

Main Methods:

• Analysis of a Polish population sample comprising 198 males.
• Development of a sequenced allelic ladder for DYS439.
• Statistical analysis of allele frequencies and population homogeneity (chi-squared test).

Main Results:

• Six of seven known DYS439 alleles were identified in the Polish sample, with allele 19 being the most frequent (0.4343).
• The calculated gene diversity for the DYS439 locus in the Polish population was 0.70, indicating high polymorphism.
• Significant statistical differences (p < 0.0000) in DYS439 allele distribution were observed between the Polish sample and populations from Italy, Portugal, and Spain.

Conclusions:

• The DYS439 locus exhibits high genetic diversity in the Polish population.
• The observed significant genetic differentiation suggests limited gene flow or distinct evolutionary histories between Poland and other studied European populations.
• DYS439 is a valuable marker for distinguishing between European populations in forensic and anthropological studies.