Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alternatives for optimal hormone replacement therapy.

R Sitruk-Ware1

  • 1Rockefeller University, New York, USA.

Climacteric : the Journal of the International Menopause Society
|December 13, 2003
PubMed
Summary

Tailored hormone replacement therapy (HRT) is crucial for women

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined nestorone-testosterone gel suppresses serum gonadotropins to concentrations associated with effective hormonal contraception in men.

Andrology·2019
Same author

Preventing secondary exposure to women from men applying a novel nestorone/testosterone contraceptive gel.

Andrology·2018
Same author

Non-clinical studies of progesterone.

Climacteric : the journal of the International Menopause Society·2018
Same author

Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone® and estradiol: pharmacokinetics from a dose-finding study.

Contraception·2018
Same author

Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects.

Journal of neuroendocrinology·2017
Same author

Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non-invasive hormonal male contraception: a randomized clinical trial.

Andrology·2017

Area of Science:

  • Reproductive Endocrinology
  • Pharmacology

Background:

  • Hormone replacement therapy (HRT) offers benefits for osteoporosis, cardiovascular disease, and dementia.
  • Patient compliance is key to HRT efficacy, necessitating acceptable formulations.
  • Individualized HRT requires careful selection of estrogens and progestogens.

Purpose of the Study:

  • To explore the development of tailored hormone replacement therapy (HRT) options.
  • To identify desirable characteristics of HRT formulations, focusing on progestogens.
  • To discuss the future of HRT in light of new compounds and delivery methods.

Main Methods:

  • Review of current HRT formulations and their components.
  • Evaluation of new progestogens, including dienogest, for their pharmacological profiles.
  • Consideration of patient preferences, medical history, and lifestyle needs.

Main Results:

  • Dienogest exhibits unique antiandrogenic properties, beneficial for HRT.
  • Tailored HRT aims to manage symptoms, minimize risks, and improve quality of life.
  • New compounds like selective estrogen receptor modulators and progestogen receptor modulators are emerging.

Conclusions:

  • Optimal HRT necessitates individualized treatment plans.
  • New progestogens and delivery systems will shape the future of HRT.
  • Future HRT strategies must address an aging population and evolving clinical trial data.

Related Experiment Videos