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Updated: Aug 29, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
[Assessment and therapeutic guideline of intermediate coronary lesions in the catheterization laboratory]
1Servicio de Cardiología. Hospital General Gregorio Marañón. Madrid. España. javbotas@jet.es
Insights
Contrast angiography has limitations in assessing intermediate coronary lesions. New diagnostic techniques are needed to determine if these lesions cause ischemia during cardiac catheterization.
Area of Science:
- Cardiology
- Medical Imaging
- Interventional Cardiology
Context:
- Contrast angiography is a long-standing method for evaluating coronary lesion severity.
- Distinguishing intermediate coronary lesions that cause ischemia remains a challenge with current angiography.
- Increasing numbers of patients undergo invasive procedures without non-invasive perfusion assessment.
Purpose:
- To review and discuss diagnostic techniques for assessing the physiological significance of intermediate coronary lesions.
- To highlight the advantages and limitations of each technique in the catheterization setting.
Summary:
- Current angiography has limitations in assessing the functional significance of intermediate coronary lesions.
- New diagnostic tools are being developed to evaluate lesion severity and guide treatment decisions.
- This review covers available techniques for assessing lesion significance in real-time during cardiac catheterization.
Impact:
- Aims to improve the diagnostic accuracy for intermediate coronary lesions.
- Supports informed clinical decision-making for patients undergoing cardiac catheterization.
- Facilitates the selection of appropriate treatments for acute coronary syndromes.
Abstract:
Contrast angiography has been used for nearly five decades to evaluate the severity of coronary lesions. However, when attempting to distinguish between intermediate coronary lesions able or unable to produce ischemia, the technique has several limitations. A large number of patients undergo cardiac catheterization without prior evaluation of coronary perfusion by non-invasive tests. This number is likely to increase in the coming years, because current recommendations favor the invasive treatment of acute coronary syndromes. This has triggered marked interest in new diagnostic techniques capable of assessing the physiological significance of intermediate lesions in the catheterization room. This paper reviews the different techniques currently available for scientifically assessing the significance of such lesions. The advantages and limitations of each are discussed.
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