Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Notch and the immune system.

Ivan Maillard1, Scott H Adler, Warren S Pear

  • 1Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

Immunity
|December 13, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Acoramidis on Kidney Function in Transthyretin Amyloid Cardiomyopathy.

Circulation. Heart failure·2026
Same author

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same author

CCL19<sup>+</sup> fibroblasts define a proliferative niche in chronic lymphocytic leukemia.

bioRxiv : the preprint server for biology·2026
Same author

Naïve CD4<sup>+</sup> T-cells and disease status at CART infusion correlate with clinical outcomes in real-world large B-cell lymphoma patients receiving second-line CAR T therapy.

Nature communications·2026
Same author

Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches.

Immunity·2026
Same author

BET inhibition blunts antibody production and macrophage-mediated fibrosis to restore lung function in murine cGVHD.

Blood·2026
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
Same journal

The transcription factor Eomes drives a stemness program in CD4<sup>+</sup> T cells that promotes anti-tumor immunity in response to immunotherapy.

Immunity·2026
Same journal

Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection.

Immunity·2026
Same journal

Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes.

Immunity·2026
Same journal

Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses.

Immunity·2026
See all related articles

The Notch pathway is vital for cell fate decisions in development and immunity. This review explores its critical roles in hematopoiesis, immune cell generation, and T cell modulation.

Area of Science:

  • Developmental biology
  • Immunology
  • Cell signaling

Background:

  • Notch proteins are key regulators of cell fate decisions across various organs.
  • The Notch pathway plays critical roles in hematopoiesis, immune cell development, and stem cell generation.
  • Recent evidence suggests Notch signaling also influences peripheral T cell differentiation and activity.

Purpose of the Study:

  • To review recent findings on the function of the Notch pathway in the hematolymphoid system.
  • To highlight the importance of understanding Notch pathway regulation in different biological contexts.
  • To elucidate the interactions between Notch signaling and other pathways in hematolymphoid development.

Main Methods:

  • Literature review of recent studies on Notch signaling in hematopoiesis and immunology.

Related Experiment Videos

  • Critical assessment of experimental data regarding Notch pathway function.
  • Synthesis of current knowledge on Notch's role in T/B cell lineage specification and stem cell generation.

    • Main Results:

    • Notch signaling is essential for T/B cell lineage specification and splenic marginal zone B cell generation.
    • Notch is crucial for the generation of hematopoietic stem cells during early embryonic development.
    • Emerging data indicate Notch pathway involvement in modulating peripheral T cell differentiation and activity.

    Conclusions:

    • The Notch pathway is a fundamental regulator of hematolymphoid system development and immune cell function.
    • Further research is needed to fully comprehend the complex regulation and interactions of the Notch pathway.
    • Understanding Notch signaling is critical for deciphering its full spectrum of effects in the hematolymphoid system.