Development of a repeatedly adjustable intraocular lens

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Materials Science

Background:

• Postoperative refractive errors remain a challenge in cataract surgery.
• Current intraocular lenses (IOLs) offer fixed focus, limiting visual correction after implantation.
• Patient needs and visual demands can change over time, necessitating adjustable vision solutions.

Purpose of the Study:

• To develop a variable-focus intraocular lens (IOL) with repeatable and reversible adjustment capabilities.
• To assess the feasibility and safety of a mechanically adjustable IOL design for clinical application.

Main Methods:

• Development of a mechanically adjustable IOL prototype using Perspex CQ poly(methyl methacrylate) (PMMA).
• Proof-of-concept testing focused on operational force measurements and prototype fabrication.
• Evaluation of mechanical adjustment mechanism viability and safety for in vivo trials.

Main Results:

• Consistent fabrication of prototype lenses was achieved.
• Operational force measurements confirmed the viability of the mechanical adjustment mechanism for repeated use.
• Low turning forces suggest safe operation without damaging ocular structures, ensuring biocompatibility and optical quality.

Conclusions:

• The mechanically adjustable IOL presents a promising approach to address postoperative refractive errors and evolving patient needs.
• The design's viability and safety for in vivo trials have been demonstrated.
• Further evaluation of biocompatibility and noninvasive adjustment is detailed in companion research.