Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-3 receptor in acute leukemia.

U Testa1, R Riccioni, D Diverio

  • 1Department of Hematology and Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy. u.testa@iss.it

Leukemia
|December 13, 2003
PubMed
Summary

Interleukin-3 receptor (IL-3R) abnormalities are common in acute myeloid leukemias (AMLs), driving leukemic cell growth. Targeting IL-3R offers a promising strategy for novel AML therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts.

Cell death & disease·2025
Same author

Striatin knock out induces a gain of function of I<sub>Na</sub> and impaired Ca<sup>2+</sup> handling in mESC-derived cardiomyocytes.

Acta physiologica (Oxford, England)·2024
Same author

Preaponeurotic endoscopic repair (REPA) indication in men could be controversial.

Hernia : the journal of hernias and abdominal wall surgery·2022
Same author

SARS-CoV-2 vaccine-associated subacute thyroiditis: insights from a systematic review.

Journal of endocrinological investigation·2022
Same author

What factors have impact on glucocorticoid replacement in adrenal insufficiency: a real-life study.

Journal of endocrinological investigation·2020
Same author

Experimental studies of boron neutron capture therapy (BNCT) using histone deacetylase inhibitor (HDACI) sodium butyrate, as a complementary drug for the treatment of poorly differentiated thyroid cancer (PDTC).

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2020

Area of Science:

  • Hematology
  • Molecular Biology
  • Oncology

Background:

  • Abnormalities of the interleukin-3 receptor (IL-3R) are frequently observed in acute myeloid leukemias (AMLs).
  • IL-3R may contribute to the proliferative advantage of leukemic blasts.
  • Overexpression of the IL-3Ralpha chain is linked to a highly malignant leukemic phenotype.

Purpose of the Study:

  • To analyze evidence linking IL-3R to AML proliferation.
  • To investigate IL-3Ralpha as a marker for leukemic stem cells.
  • To explore IL-3R as a therapeutic target in AML.

Main Methods:

  • Literature review of studies on IL-3R in AML.
  • Analysis of evidence for IL-3R's role in leukemic blast proliferation.
  • Examination of IL-3Ralpha expression in leukemic versus normal stem cells.

Related Experiment Videos

Main Results:

  • IL-3R is a target molecule stimulating AML proliferation.
  • IL-3Ralpha overexpression contributes to malignant phenotypes.
  • IL-3Ralpha is a marker of leukemic stem cells, unlike normal stem cells.

Conclusions:

  • IL-3R plays a significant role in AML pathogenesis.
  • IL-3Ralpha distinguishes leukemic stem cells from normal ones.
  • IL-3R represents a viable target for developing new anti-AML drugs.