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[Two siblings with allergic purpura following Salmonella O9 enterocolitis]
Takashi Sakano1, Keita Matsubara
1Department of Pediatrics Hiroshima Prefectural Hospital.
Insights
Two siblings developed allergic purpura following Salmonella enteritidis infection. This suggests a potential link between this bacterial infection and the development of allergic purpura, warranting further investigation.
Area of Science:
- Pediatrics
- Infectious Diseases
- Nephrology
Background:
- Allergic purpura, also known as IgA vasculitis, is a systemic vasculitis characterized by purpura, arthritis, abdominal pain, and glomerulonephritis.
- Infections are a known trigger for allergic purpura, with upper respiratory tract infections being the most common.
Observation:
- Two siblings presented with allergic purpura following Salmonella enterocolitis.
- Patient 1, a 4-year-old girl, developed joint and abdominal pain, purpura, and nephritis.
- Patient 2, a 6-year-old boy, experienced severe gastrointestinal symptoms including bloody stool.
Findings:
- Salmonella enteritidis was identified in both siblings.
- Both patients showed a favorable response to treatment, with resolution of nephritis in Patient 1 within six months.
- Patient 2's symptoms rapidly improved with intravenous hyperalimentation and prednisolone.
Implications:
- This case series suggests a potential association between Salmonella enteritidis infection and the development of allergic purpura.
- Further research and case accumulation are needed to confirm this association and elucidate the underlying pathogenesis.
- Understanding infection triggers is crucial for managing and potentially preventing allergic purpura.
Abstract:
Two siblings with allergic purpura after Salmonella O9 infection were reported. A girl (patient 1) aged 4 years and 4 months started to have knee joint pain and abdominal pain followed by purpura of the lower extremities and was referred to us for treatment of allergic purpura. She had contracted enterocolitis one month before visiting our hospital and Salmonella enteritidis was identified. During the course of the illness she had nephritis associated with allergic purpura. However, she made a favorable progress and proteinuria and hematuria disappeared within 6 months. A boy (an elder brother of patient 1) aged 6 years was admitted to our hospital because of the allergic purpura. He similarly had contracted Salmonella enterocolitis. He had severe gastro-intestinal symptoms including abdominal pain, vomiting and bloody stool, which rapidly subsided after initiation of treatment with intravenous hyperalimentation combined with prednisolone. It is possible that allergic purpura in our patients was closely associated with Salmonella enteritidis infection. Further accumulation of cases is a requisite to clarify an association of Salmonella enteritidis infection with allergic purpura and pathogenesis of allergic purpura.
