Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

First-trimester sonographic screening for Down syndrome.

Fergal D Malone1, Mary E D'Alton,

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, New York 10032, USA. fdm9@columbia.edu

Obstetrics and Gynecology
|December 16, 2003
PubMed
Summary

First-trimester nuchal translucency screening shows promise for detecting Down syndrome. This review assesses its effectiveness and practical implementation challenges for antenatal care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal Outcomes Associated With a Statewide Obstetric Hemorrhage Quality-Improvement Initiative.

Obstetrics and gynecology·2026
Same author

Overdose, Homicide, and Suicide as Causes of Maternal Death in the United States.

The New England journal of medicine·2026
Same author

Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis.

Journal of autoimmunity·2025
Same author

Implementation of a statewide bundle on obstetric hemorrhage in New York.

Pregnancy (Hoboken, N.J.)·2025
Same author

Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis.

The lancet. Diabetes & endocrinology·2025
Same author

The impact of electronic cigarettes on pregnancy and childhood health outcomes: the ECHO study-a protocol for a multicentre, prospective, observational, cohort.

Archives of gynecology and obstetrics·2025

Area of Science:

  • Prenatal diagnostics
  • Maternal-fetal medicine
  • Genetics

Background:

  • Down syndrome screening is crucial in antenatal care.
  • Current US screening combines maternal age, second-trimester markers, and ultrasonography.
  • First-trimester screening methods are gaining interest.

Purpose of the Study:

  • To objectively assess the literature on first-trimester nuchal translucency screening.
  • To evaluate adjunct first-trimester sonographic techniques.
  • To identify practical challenges for widespread implementation.

Main Methods:

  • Literature review of studies on nuchal translucency.
  • Assessment of adjunct techniques like ductus venosus flow and nasal bone studies.
  • Analysis of practical implementation issues.

Related Experiment Videos

Main Results:

  • Fetal nuchal translucency is a powerful predictor of fetal aneuploidy.
  • Adjunct techniques may enhance first-trimester screening accuracy.
  • Significant practical challenges exist for widespread clinical adoption.

Conclusions:

  • First-trimester nuchal translucency screening holds significant potential for Down syndrome detection.
  • Further research and practical solutions are needed to overcome implementation barriers.
  • Integration of these methods could advance prenatal diagnostic capabilities.