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Related Experiment Videos

A mononuclear cell component in experimental immunological glomerulonephritis.

G F Schreiner, R S Cotran, V Pardo

    The Journal of Experimental Medicine
    |February 1, 1978
    PubMed
    Summary

    This study reveals that infiltrating mononuclear phagocytes in rat kidneys are linked to immune-mediated glomerular disease and kidney dysfunction. Irradiation studies confirmed their role in nephritis progression.

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    Area of Science:

    • Nephrology
    • Immunology
    • Pathology

    Background:

    • Nephrotoxic serum nephritis is a model for immune-mediated kidney disease.
    • Understanding the cellular mechanisms driving nephritis progression is crucial.

    Purpose of the Study:

    • To investigate the role of infiltrating cells in an accelerated rat model of nephrotoxic serum nephritis.
    • To elucidate the origin and contribution of mononuclear phagocytes to glomerular injury.

    Main Methods:

    • An accelerated rat model of nephrotoxic serum nephritis was established using preimmunization.
    • Cellular infiltration and proliferation were assessed using histology and [3H]thymidine labeling.
    • Systemic irradiation was employed to ablate mononuclear cell precursors.

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    Main Results:

    • Early proteinuria correlated with neutrophilic infiltration and immune deposits.
    • Later proteinuria was associated with mononuclear cell infiltration and glomerular cell proliferation.
    • Mononuclear cells, identified as monocytes/macrophages, originated from extraglomerular precursors.
    • Irradiation-induced ablation of mononuclear cells reduced kidney infiltration and proteinuria.

    Conclusions:

    • Mononuclear phagocytes infiltrate the kidney during immunological glomerular disease.
    • These infiltrating cells may contribute significantly to the functional abnormalities observed in nephritis.
    • The findings highlight mononuclear phagocytes as potential therapeutic targets in glomerular diseases.