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The enhancement effect of gold nanoparticles as a surface modifier on DNA sensor sensitivity
Tao Liu1, Ji'an Tang, Long Jiang
1Key Laboratory of Colloid and Interface Science, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China.
Biochemical and Biophysical Research Communications
|December 16, 2003
Abstract:
The enhancement of a single strain DNA probe linked to the sensor surface is of crucial importance in DNA molecule recognition. By means of nanogold modification of the sensor surface in addition to the nanogold amplifier, DNA detection sensitivity higher than 10(-16)mol/L was obtained in a Quartz Crystal microbalance (QCM) system, much higher than the ordinary QCM sensor without surface modification by nanogold.